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. 2022 Jul 20;13:4184. doi: 10.1038/s41467-022-31798-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Body weight/tibia length ratios of control, mdx and Sirt6^mKO/mdx mice (one-way ANOVA with Bonferroni multiple comparisons test: *p = 0.0354, **p = 0.001, n = 6 for each group). b TA muscle weight/tibia length ratios of control, mdx and Sirt6^mKO/mdx mice (one-way ANOVA with Bonferroni multiple comparisons test: *p = 0.0388, ***p = 0.002, ****p < 0.0001, n = 6 for each group). c MRI analysis of muscle and fat mass of 12-week-old control (n = 7), mdx (n = 8) and Sirt6^mKO/mdx (n = 8) littermates. Scale bar: 5 mm. Quantification of muscle volume are shown on the right (one-way ANOVA with Bonferroni multiple comparisons test: *p = 0.0108, ***p = 0.0006). d Masson’s trichrome staining of the diaphragm muscle in control (n = 6), mdx (n = 5) and Sirt6^mKO/mdx (n = 5) mice (one-way ANOVA with Benjamini and Yekuteili multiple comparisons test: *p = 0.0263, *p = 0.0320, ***p = 0.0002). Scale bar: 100 μm. e Evans blue staining of diaphragm muscles from control, mdx and Sirt6^mKO/mdx mice (n = 4 for each group). Cross-sectional images of decreased myofiber leakage in Sirt6^mKO/mdx mice are shown. Scale bar: 100 μm. f Serum creatine kinase (CK) enzyme activity in control, mdx and Sirt6^mKO/mdx mice (one-way ANOVA with Bonferroni multiple comparisons test: *p = 0.0380, **p = 0.0022, ****p < 0.0001; n = 6 for each group). g Physical activity of control (n = 6), mdx (n = 9) and Sirt6^mKO/mdx (n = 9) mice in metabolic cages (PhenoMaster) (one-way ANOVA with Benjamini and Yekuteili multiple comparisons test: *p = 0.0486). Twelve to 16 weeks old male mice were used. Data are presented as mean ± SEM (a–d, f, g). Source data are provided in the Source Data file.