Figure 6.

Effects of ACR ip injection in vivo. (A) In vivo administration of ACR (100 mg/kg ip) to young rats results in weight loss next day, which is compensated the following day. Injection of MCC950 (50 mg/kg, 24 h and 2 h before ACR administration) did not alter the change in weight gain. **p < 0.01 compared with control by Student t-test. (B) ACR administered one day prior to inhibitory avoidance training results in a defect in learning as manifest by rats more readily leaving the lit chamber to enter the dark chamber where they had received a foot shock one day previously. The learning defect was overcome by administration of MCC950. **p < 0.01.