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. 2022 Jul 20;12:288. doi: 10.1038/s41398-022-02065-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A PolyI:C did not impact the number of days of gestation compared to saline-treated dams (controls) (p > 0.05; n = 9/group). B PolyI:C did not impact the number of pups born or M/F pup ratio compared to control dams (p > 0.05; n = 9/group). C Dams treated with polyI:C ate less food than control dams overall (p = 0.002; n = 9/group). D Dams treated with polyI:C drank less water than control dams 24 hours after injection (p < 0.05; n = 8/group). E PolyI:C caused a reduction in body weight 24 hours after injection, but an increase 48 hours after injection, compared to control dams (p < 0.05; n = 9/group). F The impact of polyI:C on IL6 and TNFα concentration 2 hours post-injection. Each dot represents an individual dam. PolyI:C significantly enhanced TNFα levels (p = 0.006; n = 4–5/group), but not IL6 levels (p = 0.08; n = 4–5/group).