Table 1.
KEGG pathway enrichment analysis for upregulated and downregulated genes of S. aureus-infected liver compared with culture medium.
| Hours | Pathway ID | Description | GeneRatio | BgRatio | FDR p-value |
|---|---|---|---|---|---|
| Upregulated | |||||
| 6 h | sae00020 | Citrate cycle (TCA cycle) | 15/157 | 22/963 | 0.0000 |
| sae01120 | Microbial metabolism in diverse environments | 43/157 | 132/963 | 0.0000 | |
| sae01200 | Carbon metabolism | 29/157 | 80/963 | 0.0001 | |
| 24 h | sae00997 | Biosynthesis of various secondary metabolites—part 3 | 9/208 | 10/963 | 0.0004 |
| sae01120 | Microbial metabolism in diverse environments | 48/208 | 132/963 | 0.0006 | |
| sae00290 | Valine, leucine, and isoleucine biosynthesis | 9/208 | 11/963 | 0.0006 | |
| sae00020 | Citrate cycle (TCA cycle) | 13/208 | 22/963 | 0.0018 | |
| sae01210 | 2-Oxocarboxylic acid metabolism | 11/208 | 18/963 | 0.0033 | |
| sae00650 | Butanoate metabolism | 10/208 | 16/963 | 0.0041 | |
| sae05150 | Staphylococcus aureus infection | 17/208 | 38/963 | 0.0077 | |
| sae02060 | Phosphotransferase system (PTS) | 12/208 | 23/963 | 0.0077 | |
| sae00071 | Fatty acid degradation | 7/208 | 10/963 | 0.0085 | |
| sae01100 | Metabolic pathways | 125/208 | 497/963 | 0.0204 | |
| sae02010 | ABC transporters | 28/208 | 85/963 | 0.0396 | |
| 48 h | sae00220 | Arginine biosynthesis | 15/253 | 18/963 | 0.0000 |
| sae02010 | ABC transporters | 39/253 | 85/963 | 0.0008 | |
| sae00997 | Biosynthesis of various secondary metabolites—part 3 | 9/253 | 10/963 | 0.0008 | |
| sae00340 | Histidine metabolism | 12/253 | 16/963 | 0.0008 | |
| sae00290 | Valine, leucine, and isoleucine biosynthesis | 9/253 | 11/963 | 0.0020 | |
| sae01230 | Biosynthesis of amino acids | 42/253 | 100/963 | 0.0021 | |
| sae01210 | 2-Oxocarboxylic acid metabolism | 12/253 | 18/963 | 0.0027 | |
| sae02060 | Phosphotransferase system (PTS) | 14/253 | 23/963 | 0.0030 | |
| sae02024 | Quorum sensing | 28/253 | 61/963 | 0.0032 | |
| sae05150 | Staphylococcus aureus infection | 19/253 | 38/963 | 0.0068 | |
| sae00052 | Galactose metabolism | 12/253 | 20/963 | 0.0069 | |
| sae00071 | Fatty acid degradation | 7/253 | 10/963 | 0.0216 | |
| sae01100 | Metabolic pathways | 148/253 | 497/963 | 0.0284 | |
| sae02020 | Two-component system | 29/253 | 75/963 | 0.0398 | |
| Downregulated | |||||
| 6 h | sae03010 | Ribosome | 47/297 | 73/963 | 0.0000 |
| sae00230 | Purine metabolism | 25/297 | 43/963 | 0.0041 | |
| 24 h | sae03010 | Ribosome | 46/311 | 73/963 | 0.0000 |
| sae00240 | Pyrimidine metabolism | 18/311 | 28/963 | 0.0125 | |
| sae00900 | Terpenoid backbone biosynthesis | 9/311 | 11/963 | 0.0195 | |
| 48 h | sae03010 | Ribosome | 56/460 | 73/963 | 0.0000 |
| sae00900 | Terpenoid backbone biosynthesis | 11/460 | 11/963 | 0.0065 | |
| sae00550 | Peptidoglycan biosynthesis | 20/460 | 24/963 | 0.0065 | |
| sae00240 | Pyrimidine metabolism | 22/460 | 28/963 | 0.0115 |