Table 4.
Relation Between High and Low Expression of CircANAX2 Expression with Clinical Data in AML Patients (N = 66)
| CircANAX2 Expression | Test of Sig. | p | ||||
|---|---|---|---|---|---|---|
| Low Median (<12.97) (n=33) | High Median (>12.97) (n=33) | |||||
| No. | % | No. | % | |||
| Sex | ||||||
| Male | 18 | 54.5 | 19 | 57.6 | χ2=0.062 | 0.804 |
| Female | 15 | 45.5 | 14 | 42.4 | ||
| Age (years) | ||||||
| Min. – Max. | 19.0–75.0 | 22.0–75.0 | t=1.039 | 0.303 | ||
| Mean ± SD. | 49.09 ± 15.16 | 53.0 ± 15.42 | ||||
| Median (IQR) | 50.0 | 56.0 | ||||
| Splenomegaly | 8 | 24.2 | 18 | 54.5 | χ2=6.346 | 0.012* |
| Hepatomegaly | 8 | 24.2 | 17 | 51.5 | χ2=5.216 | 0.022* |
| Lymphadenopathy | 2 | 6.1 | 2 | 6.1 | χ2=0.0 | FEp=1.000 |
| CNS involvement | 0 | 0.0 | 2 | 6.1 | χ2=2.063 | FEp=0.492 |
| B.M BLASTS | ||||||
| Min. – Max. | 20.0–90.0 | 20.0–90.0 | U=461.0 | 0.278 | ||
| Mean ± SD. | 40.52 ± 23.24 | 44.91 ± 23.70 | ||||
| Median | 30.0 | 33.0 | ||||
| FAB | ||||||
| M1 | 3 | 9.1 | 5 | 15.2 | χ2=23.474 | MCp=0.001* |
| M2 | 8 | 24.2 | 5 | 15.2 | ||
| M3 | 11 | 33.3 | 0 | 0.0 | ||
| M4 | 6 | 18.2 | 5 | 15.2 | ||
| M5 | 3 | 9.1 | 8 | 24.2 | ||
| M6 | 2 | 6.1 | 3 | 9.1 | ||
| M7 | 0 | 0.0 | 7 | 21.2 | ||
| Overall survival (months) | ||||||
| Min. – Max. | 1.0–12.0 | 1.0–12.0 | U=261.50 | <0.001* | ||
| Mean ± SD. | 10.03 ± 3.45 | 5.88 ± 4.13 | ||||
| Median | 12.0 | 4.0 | ||||
| Outcome | ||||||
| Died | 7 | 21.2 | 22 | 66.7 | χ2=15.265 | MCp<0.001* |
| Alive | 23 | 69.7 | 8 | 24.2 | ||
| Lost FU | 3 | 9.1 | 3 | 9.1 | ||
| Cytogenetic criteria | ||||||
| Favorable | 24 | 72.7 | 9 | 27.3 | χ2=17.0 | <0.001* |
| Intermediate | 7 | 21.2 | 9 | 27.3 | ||
| Adverse | 2 | 6.1 | 15 | 45.4 | ||
| CR achievement | 23 | 69.7 | 8 | 24.2 | χ2=13.687 | <0.001* |
| TLC x 103 | ||||||
| Min. – Max. | 0.80–23.0 | 1.10–21.0 | U=538.50 | 0.939 | ||
| Mean ± SD. | 8.88 ± 6.60 | 8.95 ± 6.65 | ||||
| Median | 7.50 | 7.0 | ||||
| Hb gm/dl | ||||||
| Min. – Max. | 3.0–11.80 | 4.90–11.30 | t=0.411 | 0.682 | ||
| Mean ± SD. | 8.45 ± 1.86 | 8.26 ± 1.86 | ||||
| Median | 8.30 | 8.80 | ||||
| PLT x 103 | ||||||
| Min. – Max. | 17.0–120.0 | 10.0–150.0 | U=521.0 | 0.763 | ||
| Mean ± SD. | 55.61 ± 25.84 | 54.73 ± 32.83 | ||||
| Median | 55.0 | 56.0 | ||||
Notes: p, p-value for comparing between different parameters *statistically significant at p ≤ 0.05.
Abbreviations: χ2, chi-square test; MC, Monte Carlo; FE, Fisher Exact; t, Student’s t-test, U; Mann Whitney test.