Table 5.
Relation Between Low and High Expression of Circ0075001expression with Clinical Data in AML Patients (N = 66)
| Circ0075001 Expression | Test of Sig. | p | ||||
|---|---|---|---|---|---|---|
| Low Median (<3.01) (n=33) | High Median (>3.01) (n=33) | |||||
| No. | % | No. | % | |||
| Sex | ||||||
| Male | 21 | 63.3 | 16 | 48.5 | χ2=1.538 | 0.215 |
| Female | 12 | 36.4 | 17 | 51.5 | ||
| Age (years) | ||||||
| Min. – Max. | 24.0–75.0 | 19.0–75.0 | t=1.236 | 0.221 | ||
| Mean ± SD. | 48.73 ± 13.17 | 53.36 ± 17.06 | ||||
| Median | 49.0 | 58.0 | ||||
| Splenomegaly | 5 | 15.2 | 21 | 63.6 | χ2=16.246 | <0.001* |
| Hepatomegaly | 5 | 15.2 | 20 | 60.6 | χ2=14.488 | <0.001* |
| Lymphadenopathy | 1 | 3.0 | 3 | 9.1 | χ2=1.065 | FEp=0.613 |
| CNS involvement | 0 | 0.0 | 2 | 6.1 | χ2=2.063 | FEp=0.492 |
| B.M BLASTS | ||||||
| Min. – Max. | 20.0–90.0 | 20.0–90.0 | U=522.50 | 0.775 | ||
| Mean ± SD. | 44.88 ± 24.77 | 40.55 ± 22.11 | ||||
| Median (IQR) | 32.0 | 30.0 | ||||
| FAB | ||||||
| M1 | 3 | 9.1 | 5 | 15.2 | χ2=22.144 | MCp=0.001* |
| M2 | 12 | 36.4 | 1 | 3.0 | ||
| M3 | 8 | 24.2 | 3 | 9.1 | ||
| M4 | 6 | 18.2 | 5 | 15.2 | ||
| M5 | 2 | 6.1 | 9 | 27.3 | ||
| M6 | 1 | 3.0 | 4 | 12.1 | ||
| M7 | 1 | 3.0 | 6 | 18.2 | ||
| Overall survival (months) | ||||||
| Min. – Max. | 1.0–12.0 | 1.0–12.0 | U=273.0 | <0.001* | ||
| Mean ± SD. | 10.0 ± 3.44 | 5.91 ± 4.17 | ||||
| Median | 12.0 | 4.0 | ||||
| Outcome | ||||||
| Died | 10 | 30.3 | 19 | 57.6 | χ2=10.693 | MCp=0.004* |
| Alive | 22 | 66.7 | 9 | 27.3 | ||
| Lost FU | 1 | 3.0 | 5 | 15.2 | ||
| Cytogenetic criteria | ||||||
| Favorable | 23 | 69.6 | 10 | 30.4 | χ2=10.25 | P=0.005* |
| Intermediate | 5 | 15.2 | 11 | 33.3 | ||
| Adverse | 5 | 15.2 | 12 | 33.3 | ||
| CR achievement | 23 | 69.7 | 8 | 24.2 | χ2=13.687 | <0.001* |
| TLC x 103 | ||||||
| Min. – Max. | 0.80–23.0 | 1.10–21.0 | U=519.50 | 0.748 | ||
| Mean ± SD. | 9.32 ± 6.93 | 8.51 ± 6.28 | ||||
| Median | 7.50 | 6.20 | ||||
| Hb gm/dl | ||||||
| Min. – Max. | 5.0–11.80 | 3.0–11.30 | t=2.197 | 0.032* | ||
| Mean ± SD. | 8.84 ± 1.54 | 7.87 ± 2.02 | ||||
| Median | 9.0 | 7.50 | ||||
| PLT x 103 | ||||||
| Min. – Max. | 17.0–150.0 | 10.0–100.0 | U=472.0 | 0.352 | ||
| Mean ± SD. | 58.97 ± 30.77 | 51.36 ± 27.74 | ||||
| Median | 55.0 | 50.0 | ||||
Notes: p, p-value for comparing between different parameters *statistically significant at p ≤ 0.05.
Abbreviations: χ2, chi-square test; MC, Monte Carlo; FE, Fisher Exact t: Student’s t-test; U, Mann Whitney test.