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When mTNFα binds to TNFR2, MDSCs, CD4+Tregs, CD8+Tregs, and Bregs are activated. This increases CD4+Treg and CD8+Treg stability and expansion. It stimulates production of anti-inflammatory cytokines such as IL-10 and TGF-β. It inhibits CD4+ T effector cell function. It promotes upregulation of immunoglobulin A (IgA) B cells.
