Table 3.
CCI identified within and between proximal tubule and endothelial ST-spots.
|
|
|
|---|---|---|
| Transportation and signaling | ||
| APOE-LRP2 | APOE-LRP2 | (156) |
| APP-CD74 | APP-CD74 | (133) |
| ALB-LRP2 | ALB-LRP2 | (157) |
| APOE-LDLR | APOE-LDLR | (158) |
| SERPINE1-LRP2 | SERPINE1-LRP2 | (159) |
| TIMP1-CD63 | TIMP1-CD63 | (160, 161) |
| Adhesion | ||
| THBS1-ITGB1 | THBS1-ITGB1 | (162, 163) |
| COL18A1-ITGB1 | COL18A1-ITGB1 | (130, 164, 165) |
| PLG-ITGB1 | PLG-ITGB1 | (166) |
| SPP1-ITGB5 | SPP1-ITGB5 | (167) |
| SPP1-ITGB1 | SPP1-ITGB1 | (94, 168) |
| SPP1-ITGAV | SPP1-ITGAV | (92, 169) |
| SPP1-CD44 | SPP1-CD44 | (170) |
| EPCAM- EPCAM | EPCAM- EPCAM | (171) |
| Immune modulation | ||
| HLA-B-CANX | HLA-B-CANX | (146, 172) |
| HLA-A-APLP2 | HLA-A-APLP2 | (143, 173, 174) |
| MIF-CD74 | MIF-CD74 | (175) |
| HLA-ERBB2 | HLA-ERBB2 | (163) |
| Angiogenic regulation | ||
| THBS1-SDC1 | THBS1-SDC1 | (64) |
| THBS1-SDC4 | THBS1-SDC4 | (64, 176, 177) |
The literature based location of the top 20 PT-PC L–R gene pairs were confirmed in sc/snRNA-seq datasets, as an expression within proximal tubule (segments 1, 2, and 3), peritubular capillary, and endothelial cell types. In particular, the sc/snRNA-seq datasets within the Kidney Interactive Transcriptomics (Healthy Adult Kidney—Epithilia (57), Healthy Mouse Dataset (58), Human Diabetic Kidney (59) and Human Kidney snRNA/ATAC-seq (60), and The Human Nephrogenesis Atlas [Human week 14 scRNA-seq (61)] were utilized.