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. 2022 Jul 7;109(7):1272–1285. doi: 10.1016/j.ajhg.2022.05.015

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Local genetic correlation between uterine leiomyoma and breast cancer

(A) Manhattan plot showing the estimates of local genetic correlation, genetic covariance, and SNP heritability between uterine leiomyoma and breast cancer overall. Red bars represent loci showing significant local genetic correlation after multiple testing adjustment (p < 0.05/1,703).

(B) QQ-plot presenting region-specific p values from local genetic correlation between uterine leiomyoma and breast cancer overall.

(C) Manhattan plot showing the estimates of local genetic correlation, genetic covariance, and SNP heritability between uterine leiomyoma and ER+ breast cancer. Red bars represent loci showing significant local genetic correlation after multiple testing adjustment (p < 0.05/1,703).

(D) QQ-plot presenting region-specific p values from local genetic correlation between uterine leiomyoma and ER+ breast cancer. UL, uterine leiomyoma; BC, breast cancer; ER, estrogen receptor.