TABLE 6.

Performance per disease category.

	PRISM III			PIM III
	SMR (95% CI)	ROC curve		SMR (95% CI)	ROC curve
		AUC (95% CI)	P-value		AUC (95% CI)	P-value
All patients	2.61 (2.27–2.96)	0.81 (0.79–0.84)	<0.001	2.75 (2.56–2.93)	0.80 (0.77–0.82)	<0.001
All excluding DNR	1.52 (1.24–1.80)	0.87 (0.84–0.90)	<0.001	1.64 (1.49–1.80)	0.82 (0.79–0.86)	<0.001
Disease group
Immunological	4.27 (1.48–7.05)	0.79 (0.59–0.98)	0.025	2.82 (0.98–4.66)	0.69 (0.46–0.93)	0.133
Metabolic/genetic	2.72 (0.71–4.74)	0.93 (0.87–0.99)	<0.001	1.97 (0.51–3.42)	0.71 (0.53–0.90)	0.057
Renal	1.28 (0.26–2.30)	0.86 (0.67–1.00)	0.003	2.90 (0.58–5.22)	0.78 (0.59–0.96)	0.023
Endocrine	2.44 (–2.34–7.22)	0.93 (0.90–0.97)	0.136	0.95 (–0.91–2.82)	0.99 (0.98–1.00)	0.089
CNS disease	2.80 (1.75–3.86)	0.90 (0.85–0.94)	<0.001	2.95 (1.84–4.07)	0.88 (0.82–0.95)	<0.001
Cardiovascular disease	1.97 (0.51–3.42)	0.80 (0.65–0.95)	0.011	2.27 (0.59–3.94)	0.58 (0.41–0.75)	0.511
GI/hepatic	1.04 (–0.40–2.47)	0.86 (0.66–1.00)	0.081	1.06 (–0.41–2.54)	0.92 (0.83–1.00)	0.041
Hematological	1.52 (–1.45–4.48)	1.00 (1.00–1.00)	0.091	2.04 (–1.96–6.04)	0.93 (0.85–1.00)	0.149
Infections	2.50 (1.88–3.13)	0.77 (0.71–0.84)	<0.001	4.01 (3.01–5.01)	0.74 (0.68–0.80)	<0.001
Respiratory	2.75 (2.13–3.38)	0.72 (0.66–0.79)	<0.001	2.68 (2.07–3.29)	0.85 (0.77–0.93)	<0.001
Malignancies	4.74 (2.71–6.77)	0.84 (0.76–0.92)	<0.001	2.45 (1.40–3.50)	0.82 (0.63–1.00)	0.016
Other	1.51 (0.19–2.83)	0.86 (0.70–1.00)	0.006	1.06 (0.13–1.99)	0.73 (0.67–0.78)	<0.001

The P-value corresponding to χ2 was calculated as (observed deaths − expected deaths)²/expected deaths with one degree of freedom. AUC, Area Under the Curve; CI, confidence interval; CNS, central nervous system; DNR, do-not-resuscitate; PIM, Pediatric Index of Mortality; PRISM, Pediatric Risk of Mortality; ROC, receiver operating characteristic, SMR, standardized mortality ratio.