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. 2022 Jul 7;9:904078. doi: 10.3389/fmed.2022.904078

TABLE 3.

The experimental animal models of pancreatitis-associated ALI.

Models induced Model Function References
Sodium taurocholate Rat Emodin protects against acute pancreatitis associated lung injury by Inhibiting NLPR3 inflammasome activation via Nrf2/HO-1 signaling (93)
Deoxycholic acid sodium salt Rat The ICAM-1-mediated JAK2/STAT3 signaling cascade was able to enhance inflammatory responses (94)
Caerulein Rat Inhibition of MMP-9 activity with doxycycline reduced pancreatitis-associated lung injury (95)
Caerulein and LPS Mouse Activation of Nrf2/ARE may be a promising therapeutic target (74)
L-arginine Mouse Reduces acute lung injury by reducing the infiltration of inflammatory cells and inhibiting inflammatory cytokine secretion and cell apoptosis by inhibiting the activation of JAK2-STAT3 signaling (96)