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Development of T-follicular helper cells: Artwork shows TFH cell development in the lymphoid follicle. Interaction of naïve T-cell and dendritic cells in the outer T-cell zone prime the lymphocytes which in the respective cytokine milieu mature into the T-lymphocyte subsets. Activated T-cell with CXCR5 upon interaction with B-cell in the lymphoid follicle mature into the TFH cell and share a symbiotic relationship with B-cells.
