Table 5.

Comparison of MBL, C3a and cytokines levels in patient with CHIKV infection according to presence/persistence of musculoskeletal disorder in acute and chronic phases

Mediator	Acute phase (AP) Musculoskeletal disorder Median (IQR) pg/µL			Chronic phase (CP) Musculoskeletal disorder Median (IQR) pg/µL			P value** Presence (AP) vs. Persistence (CP)
	Presence n = 62	No presence n = 21	P value* Presence/No presence	Persistence n = 28	No persistence n = 55	P value* Persistence/No persistence
MBL	2.3 (1.2-3.8)	2.5 (1.0-3.7)	0.853	1.4 (1.0-2.9)	1.9 (0.9-3.5)	0.398	0.425
C3a	122.7 (66.6-253.3)	68.5 (64.5-71.2)	0.022	190.9 (72.5-248.2)	68.4 (63.2-164.1)	< 0.001	0.501
IFN-γ	59.4 (18.3-139.7)	72.1 (47.8-183.7)	0.166	31.0 (1.2-72.6)	61.8 (40.6-150.3)	0.005	0.101
TNF-α	11.0 (0.0-25.8)	12.0 (3.7-28.1)	0.467	5.3 (0.0-44.7)	14.6 (4.7-27.5)	0.198	0.502
IL-6	12.8 (0.0-45.0)	47.5 (23.5-94.9)	0.002	7.9 (2.4-32.8)	23.0 (8.6-77.6)	0.004	0.510
IL-12	1.8 (0.0-9.7)	1.4 (0.1-2.7)	0.496	0.3 (0.0-14.1)	4.6 (0.5-14.1)	0.090	0.398
IL-10	26.4 (13.5-51.4)	34.3 (19.6-60.4)	0.341	11.6 (7.9-19.5)	20.8 (14.4-30.0)	0.001	0.002
IL-8	82.1 (23.2-243.8)	67.9 (34.9-781.6)	0.516	20.4 (10.5-41.3)	104.7 (20.0-742.0)	0.002	0.112
MIP-1	23.9 (3.1-50.2)	17.8 (8.7-49.2)	0.963	3.4 (0.0-13.7)	16.1 (0.0-36.6)	0.008	0.002
MCP-1	229.0 (148.8-342.5)	144.7 (106.9-193.3)	0.008	223.7 (124.8-352.8)	176.1 (119.9-268.4)	0.149	0.349
RANTES	5153.0 (4495.8-10923.1)	5201.4 (4401.9-9539.6)	0.554	7721.1 (4759.8-14824.1)	5226.1 (4676.9-6965.7)	0.037	0.918

^*Mann-Whitney test;

^**Wilcoxon test.