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. 2022 Jul 7;13:928419. doi: 10.3389/fphar.2022.928419

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Copyright © 2022 Wang, Qu, Chen, Pan, Tang, Hu, Gao, Niu, Liu, Gao and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between lactate metabolism scores and tumor immunity in breast cancer and thyroid cancer. (A,B) Relationship between lactate metabolism scores in THCA and BRCA and expression of immune cytolytic activity (CYT), interferon (IFN), tumor-infiltrating lymphocytes (TILs), and human leukocyte antigen (HLA). (C,D) The relationship between the expression of lactate metabolism-related genes in THCA and BRCA and that of CYT, IFN, TILs, and HLA. (E,F) Differences in the infiltration of macrophages and CD4+T cells in THCA between high and low lactate metabolism score groups. (G,H) Differences in the infiltration of macrophage and CD4+T cells in BRCA between high and low lactate metabolism score groups.