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. 2022 Jul 7;13:928419. doi: 10.3389/fphar.2022.928419

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Copyright © 2022 Wang, Qu, Chen, Pan, Tang, Hu, Gao, Niu, Liu, Gao and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Drug sensitivity analysis of patients with high and low lactate metabolism scores of breast cancer and thyroid cancer. (A,B) The GDSC database predicts the difference in sensitivity of patients with high and low lactate metabolism scores to different anticancer drugs, and 10 drugs with the most significant difference are ranked according to the p-values. (C,D) The difference in the susceptibility of patients with high and low lactate metabolism scores to immunotherapy and associated biomarkers as predicted by the TIDE algorithm.