Table 1.

Summary of the clinical significance of MA

►	It is part of the degeneration of the dopaminergic nigrostriatal system.
►	It is a marker of global dysfunction in the mesocorticolimbic network.
►	It begins in early-stage PD.
►	It precedes clinical phenotype.
►	It is correlated with mild cognitive impairment.
►	It is correlated with apathy.
►	It is correlated with (the presence and severity of) disinhibition.
►	It is correlated with impulsive behavior.
►	It is correlated with cerebral small-vessel disease progression.

MA, Mavridis’ atrophy; PD, Parkinson’s disease.