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. 2022 Jul 7;12:845931. doi: 10.3389/fonc.2022.845931

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Copyright © 2022 Li, Wang, Wan, Ma, Qi and Gu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA-seq in HCT116 cell lines revealed that hnRNPK from hnRNPK/A1/R/U complex mainly regulated cellular transcription and translation. (A) To identify the biological functions of hnRNPK in colorectal adenocarcinoma cells, the primary biological processes that hnRNPK is involved in were analyzed by RNA-seq in HCT116 cells. The heatmap was constructed after hnRNPK knockdown. (B) By GO analysis of the differential genes, regulation of transcription by RNA polymerase II was identified as the primary biological function of hnRNPK. (C, D) Regulation of transcription by RNA polymerase II and translation by ribosome were identified as the primary biological processes according to the GSEA. (E, F) In FHC cells, the primary biological functions of hnRNPK were further analyzed by RNA-seq. By GO analysis of the differential genes, regulation of DNA binding was identified as the primary biological function of hnRNPK. KEGG pathway analysis confirmed that the differential genes were mainly enriched in metabolism signaling pathway.