TABLE 1.
The fixed parameters of the semi-PBPK model.
| Parameter | Value | Unit | Definition | Source |
|---|---|---|---|---|
| FA | 0.900 | Fraction of absorbed drug following entry into the gastrointestinal tract | Reference, Xiao et al. (2009) | |
| fu, ELF | 1 | Fraction of unabsorbed drug in the epithelial lining fluid | Default | |
| fu,tissue | 1 | Fraction of unabsorbed drug in the respiratory tract tissue | Default | |
| fu,p | 0.800 | Fraction of unabsorbed drug in plasma | Reference, Faessel et al. (2010) | |
| kmcc,bb | 0.083 | h−1 | Elimination rate due to bronchiolar ciliary peristalsis | Reference, Plowchalk et al. (1997) |
| kmcc,BB | 0.417 | h−1 | Elimination rate due to bronchial ciliary peristalsis | Reference, Plowchalk et al. (1997) |
| VNose-ELF | 2.459*10–4 | L | The volume of nasal epithelial lining fluid | Reference, Polak et al. (2019) |
| VBB-ELF | 0.0021 | L | The volume of bronchial epithelial lining fluid | Reference, Plowchalk et al. (1997) |
| Vbb-ELF | 0.0021 | L | The volume of bronchiolar epithelial lining fluid | Reference, Plowchalk et al. (1997) |
| VAL-ELF | 0.0208 | L | The volume of alveolar epithelial lining fluid | Reference, Plowchalk et al. (1997) |
| VNose-tissue | 2.828*10–3 | L | The volume of nasal mucosal tissue | Reference, Polak et al. (2019) |
| VBB-tissue | 0.038 | L | Volume of bronchial mucosal tissue | Reference, Plowchalk et al. (1997) |
| Vbb-tissue | 0.038 | L | Volume of bronchiolar tissue | Reference, Plowchalk et al. (1997) |
| VAL-tissue | 0.381 | L | The volume of alveolar tissue | Reference, Plowchalk et al. (1997) |
| PSNose | 0.0045 | L/h | The permeation elimination rate of the nasal mucosa | Calculated |
| PSBB | 0.138 | L/h | Permeation elimination rate of bronchial mucosa | Calculated |
| PSbb | 0.138 | L/h | Permeation elimination rate of bronchiolar mucosa | Calculated |
| PSAL | 25.728 | L/h | The permeation elimination rate of the alveolar inner wall | Calculated |