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. 2022 Jul 7;10:952500. doi: 10.3389/fbioe.2022.952500

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Copyright © 2022 Wu, Zhao, Lin and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The osteogenic activity and mechanism of PDA-coated Ti, PEEK and HA substrates. (A) The enhancement of cell proliferation and osteogenic differentiation of BMSCs on PDA-coated substrates. (B) The enhanced osseointegration of PDA-modified PEEK implants via histomorphometry analysis. (C) Western blot experiments and quantitative analysis of the expression of FAK, p-FAK, and MAPK signaling pathways proteins of BMSCs after culturing for 48 h. (D) Schematic diagram for the mechanism of enhanced osteogenic differentiation and osseointegration of PDA coating. (*p < 0.05) (Wang H. et al., 2019). Copyright 2019, American Chemical Society.