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Schematic illustration for the effect of immunomodulation on osteogenesis via the PDA-based peptide-loaded coating. The peptide binds steadily to the Ti implant with the assistance of PDA. Under the LPS-induced inflammatory conditions, the biomimetic osteogenic peptide coating exhibited antiinflammatory property and changed the macrophages to the M2 phenotype, which in turn enhanced new bone formation (Bai et al., 2020). Copyright 2020, Elsevier.
