TABLE 4.
Synergistic enhancement of multiple components and functions for new bone formation.
| Functions | Substrates | PDA-mediated components | Techniques | Advantages | References |
|---|---|---|---|---|---|
| Osteogenesis | Silk membrane | Chemokine | Dip-coating | Enhanced BMSCs recruitment, osteogenic differentiation and new bone formation | Wu et al. (2019) |
| Osteogenesis | HA | Poly(L-lysine), BMP-2 | Dip-coating | Sustainable drug releasing, enhanced osteogenic differentiation and bone formation of ectopic bone | Han et al. (2019) |
| Angiogenesis and osteogenesis | PCL/HA | BMP-2, VEGF. | Dip-coating | Synergistic enhancement of osteogenesis | Godoy-Gallardo et al. (2020) |
| Angiogenesis and osteogenesis | Ta | Sr | Dip-coating | Enhanced angiogenesis and osseointegration in rat femur | Cheng et al. (2021) |
| Antiinflamma-tion and osteogenesis | Ti | Osteogenic growth peptide | Dip-coating | Suppression of osteoclastogenesis and promotion of osteogenesis | Bai et al. (2020) |
| Antibiosis and osteogenesis | Zn | Sr-doped HA | Electroch-emical deposition | Corrosion resistance, antibacterial property and enhanced osteogenic activity | Bingbing Wang et al. (2021) |
| Antibiosis and osteogenesis | PEEK | Ag, CuO, silk fibroin | Spin-coating | PH-response, antibacterial property, enhanced osteogenic activity both in vitro and in vivo | Yan et al. (2020) |
| Antitumor and osteogenesis | Mg alloy | Doxorubicin | Dip-coating | Tumor suppression, photothermal property | Shao et al. (2021) |