Table 3.
Multivariable analysis evaluating predictors of grade 2-4 acute GVHD, chronic GVHD and chronic GVHD requiring immunosuppressive therapy.
| Predictor | Grade 2-4 acute GVHD D180 | Chronic GVHD 3 yrs | Chronic GvHD requiring IS therapy 3 yrs | ||||
|---|---|---|---|---|---|---|---|
| HR(95% CI) | P | HR(95% CI) | P | HR(95% CI) | P | ||
|
SIRPα
Mismatched |
1.3 (0.9-1.9) |
0.2 |
1.8 (1.2-2.6) |
0.002 |
1.9 (1.2-2.9) |
0.005 |
|
|
Donor/recipient gender
Female / Male |
1.6 (1.05-2.4) |
0.03 |
1.9 (1.3-2.9) |
0.001 |
2.03 (1.3-3.2) |
0.002 |
|
|
Conditioning regimen
Myeloablative |
1.8 (1.2-2.7) |
0.004 |
0.7 (0.5-0.9) |
0.04 |
0.8 (0.5-1.2) |
0.2 |
|
GVHD: graft-versus-host disease; IS: immunosuppressive.