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. 2022 Jul 7;13:944495. doi: 10.3389/fmicb.2022.944495

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Copyright © 2022 Wang, Xing, Ji, Xi, Liu, Yang, Lei, Han and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pc combined with FMT completely removed S. Typhimurium in vivo. (A) The antibacterial effect of single phage and Pc on S. Typhimurium in vitro at MOI = 0.1. Each independent experiment was repeated three times. The bacterial loads (B) and phage titres (C) in the colonic tissues of healthy, bacterially infected, single phage-treated and Pc-treated mice. (D) The bacterial loads in the colonic tissues of the bacterial-infected, single Pc-treated, and PcFMT-treated mice. Data are expressed as the means ± SEM, n = 6. *P < 0.05; **P < 0.01; ***P < 0.001.