FIGURE 5.

Therapeutic effect of PcFMT on mouse colitis caused by S. Typhimurium. The colonic tissues were collected from healthy, bacterial-infected, single-dose Pc-treated, FMT-treated, and PcFMT-treated mice 48 h after S. Typhimurium (0.2 mL, 4 × 10⁸ CFU/mouse) infection. “Unt” represents untreated healthy mice group; “Bai” represents the bacterial-infected mice group; “Pc” means phage cocktail-treated mice group; “PcFMT” represents the combined phage cocktail and FMT mice group. (A) The transcription levels of the tight junction proteins Occludin, Claudin-3 and ZO-1. (B) The transcription levels of epithelial mucus Mucin 1 and Mucin 2 in colonic tissues. Data are the means ± SEM, n = 6. *P < 0.05; **P < 0.01; ***P < 0.001 indicate a significant difference.