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. 2022 Jul 7;15:868563. doi: 10.3389/fnmol.2022.868563

Figure 1.

Figure 1

An experimental model of cervical SCI in adult mice and behavioral devices. (A) Schematic representation of C5 SCI experimental model. The region in dark gray represents the lesion site. (B) Coronal section of the injured spinal cord stained using GFAP and NeuN antibodies (DPI, days post-injury; D, dorsal; V, ventral). DAPI stained nuclei. Scale bar, 200 μm. (C) Quantification of (B). Mean and SEM (paired 2-tailed Student's t-test ***p < 0.001, n = 5 biological replicates). (D) Experimental scheme. (E) Representative photographs of the treadmill apparatus in a standard and open (group runs) configuration. (F–H) Representative photographs of the skilled walking device. Mice were trained to cross the ladder from right (empty cage) to left (fun cage).

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