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. 2022 Jul 4;3(4):zqac034. doi: 10.1093/function/zqac034

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© The Author(s) 2022. Published by Oxford University Press on behalf of American Physiological Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Txnrd1-deficient β-cells have altered expression of genes involved in heme metabolism and glutathione metabolism. (A and B) Heat map showing Log₂ (RPKM) of selected genes involved in heme metabolism (A) or glutathione metabolism (B) in Txnrd1^+/+, Ins1^Cre/+ (+/+; Cre⁺) and Txnrd1^fl/fl, Ins1^Cre/+ (fl/fl; Cre⁺) β-cell samples as determined by RNA-sequencing. All genes shown are significantly different between the genotypes. (C) Measurement of total glutathione levels in Txnrd1^fl/fl, Ins1^+/+ (fl/fl) and Txnrd1^fl/fl, Ins1^Cre/+ (Cre⁺) islets. Results are the average of 3–4 independent experiments with statistical significance indicated. *P <0.05 (vs. fl/fl).