TABLE 1.
Patient Characteristics, N = 136
| No. of Patients (%) |
||
|---|---|---|
| Characteristic | Germline BRCA Cohort | Somatic BRCA Cohort |
| Sex | gBRCA, n = 116 | sBRCA, n = 20 |
| Men | 66 (57) | 8 (40) |
| Women | 50 (43) | 12 (60) |
| Age at diagnosis, y | ||
| Median [range], y | 60 [33-82] | 63 [25-83] |
| <40 | 4 (3) | 1 (5) |
| 40-49 | 10 (9) | 2 (10) |
| 50-59 | 42 (36) | 4 (20) |
| 60-69 | 33 (28) | 6 (30) |
| 70-79 | 22 (19) | 6 (30) |
| >80 | 5 (4) | 1 (5) |
| Histology | ||
| Adenocarcinoma | 112 (96) | 19 (95) |
| Adenosquamous | 1 (1) | – |
| Acinar | 3 (3) | 1 (5) |
| Stage at diagnosis | ||
| I/II | 30 (26) | 5 (25) |
| III | 17 (15) | 3 (15) |
| IV | 69 (59) | 12 (60) |
| Personal history of BRCA-assoc cancer | ||
| Yes | 27 (23) | 0 (0) |
| Type of BRCA-assoc cancer: Personal history | gBRCA, n = 27 | sBRCA, n = 1 |
| Breast | 19 (71) | – |
| Prostate | 6 (22) | – |
| Breast and ovarian | 2 (7) | – |
| BRCA-assoc cancer in first-degree relatives | gBRCA, n = 116 | sBRCA, n = 20 |
| Yes | 65 (56) | 4 (20) |
| Pancreatic cancer in first-degree relatives | ||
| Yes | 12 (10) | 1 (5) |
| Type of BRCA mutation | ||
| BRCA1 | 33 (28) | 4 (20) |
| BRCA2 | 83 (72) | 16 (80) |
| Zygosity | ||
| Biallelic | 65 (89) | 12 (60) |
| Heterozygous | 8 (11) | 8 (40) |
| Unknown/indeterminate | 43 | |
| AJ founder gBRCA mutation | ||
| Yes | 59 (51) | – |
| No | 57 (49) | – |
| Tumor mutation burden: Median [range], mt/Mb | 4.40 [0.0-13.2] | 5.10 [1.80-9.70] |
Abbreviations: AJ, Ashkenazi Jewish; assoc, associated; gBRCA, germline BRCA mutation; sBRCA, somatic BRCA mutation; mt/Mb, mutations per megabase.