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. 2022 Jul 7;13:934755. doi: 10.3389/fneur.2022.934755

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Copyright © 2022 Gaulee, Yang, Sura, Xu, Rossignol, Weiss and Bliznyuk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of neuroprotein Biomarkers GFAP, NFL, Tau, UCHL-1 among Control, low cord pH neonates and moderate-severe HIE neonates. Compared to Control group, serum concentrations of GFAP, NFL and Tau were higher in low cord pH group (P < 0.05) and moderate -severe HIE group (P < 0.001). The concentrations of UCHL-1 were increased in neonates with moderate-severe HIE compared to control neonates (P < 0.001). Concentrations of UCH-L1 was not different between controls and neonates with low cord pH, with/without mild HIE, at 0–6 h of life. Compared to moderate-severe HIE, serum concentration of NFL was lower in mild HIE group (P < 0.01).