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. 2022 Jul 7;13:925276. doi: 10.3389/fphar.2022.925276

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Copyright © 2022 He, Yao, Yang, Wang, Liu, Cao, Chen, Fu, Yang, Wang, He and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myocardial apoptosis. (A) Representative TUNEL-α-actinin immunofluorescence double staining in each group. The myocardial cells were labeled with α-actinin and stained red, while the apoptotic nuclei were stained green. (B) Quantitative analysis of TUNEL staining by FITC/DAPI in each group. (C) Representative bands of Bax and Bcl-2 in each group. (D) and (E) Quantitative analysis of Bax and Bcl-2 expression in each group. ^** p < 0.01 vs. the control group. ^# p < 0.05 vs. the METH group, ^## p < 0.01 vs. the METH group. METH, methamphetamine; DAPA, dapagliflozin; Bax, Bcl-Associated X; Bcl-2, B-cell lymphoma-2.