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. 2022 Jul 7;13:925276. doi: 10.3389/fphar.2022.925276

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Copyright © 2022 He, Yao, Yang, Wang, Liu, Cao, Chen, Fu, Yang, Wang, He and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Signaling pathway protein expression. (A) Representative image of cleaved caspase3 by immunohistochemistry in each group. (B) Quantitative analysis of cleaved caspase3 by immunohistochemistry in each group. (C) Representative image of GRP78 by immunohistochemistry in each group. (D) Quantitative analysis of GRP78 by immunohistochemistry in each group. (E) Representative bands of cleaved caspase3 and caspase9 in each group. (F) and (G) Quantitative analysis of the expression of cleaved caspase3 and caspase9 in each group. (H) Representative bands of Cyt-C, cIAP1 in each group. (I) and (J) Quantitative analysis of the expression of Cyt-C and cIAP1 in each group. ^* p < 0.05 vs. the control group, ^** p < 0.01 vs. the control group.^# p < 0.05 vs. the METH group, ^## p < 0.01 vs. the METH group. METH, methamphetamine; DAPA, dapagliflozin; cl-caspase3, cleaved caspase3; GRP78, glucose regulated protein; Cyt-C, cytochrome C; cIAP1, inhibitor of apoptosis 1.