Figure 4. Tacrolimus up-regulates expression of transforming growth factor β receptor type II (TGFβ-RII) and phosphorylation of SMAD family members 2/3 (p SMAD2/3) in intestinal epithelial cells. Western blot analysis of expression of TGFβ-RII (A), TGFβ-RI (B) and SMAD2/3 phosphorylation (C) in intestinal epithelial cells 24 h after tacrolimus treatment. Data are expressed as the mean±standard deviation (n=4 mice per group). GAPDH: Glyceraldehyde 3-phosphate dehydrogenase. Significantly different at: *p<0.05 and **p<0.01.
