Figure 6. Transforming growth factorβ receptor type II (TGFβ-RII) expression is up-regulated in Caco-2 cells by tacrolimus via the extracellularsignal-regulated kinase pathway. A: Western blot analysis of TGFβ-RII expression in Caco-2 cells. Caco-2 cells were pretreated with the vehicle, or p42/44 mitogen-activated protein kinase inhibitor U0126 or p38 mitogen-activated protein kinase inhibitor SB203580 (0.1 mM) before tacrolimus treatment. Data are expressed as the mean±standard deviation (n=6 per group). GAPDH: Glyceraldehyde 3-phosphate dehydrogenase. *Significantly different at p<0.05.
