Figure 2. The role of circulating microRNAs in the cellular pathways involved in papillary thyroid carcinoma. Protein phosphatase 2 regulatory subunit B alpha (PPP2R2A) (51), tumor growth factor β (TGF-β) (2), WNT/β-catenin (24), thyroid hormone receptor β (THRB) (51), Retinoblastoma 1 gene (51), intracellular cell adhesion molecular-1 (ICAM1) (34), PI3K/Akt (25), vascular endothelial growth factor (25), MEKK/ERK1/2 (61), EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) (26), complex G protein-coupled receptor kinase 2 (GRK2) (28), PAX 8 (55), transmembrane protein with EGF-like and 2 follistatin domain (TMEFF2) (55), gene encoding type IV collagen α1 (COL4A1) (29), cyclin-dependent kinase inhibitor 1B (CDKN1B) (46), suppressor of cytokine signaling 4 (SOCS4) (47), cytochrome P450 Family 11 Subfamily B Member 1 (CYP11B1) (62), epithelial to mesenchymal transition (EMT) (31) (Created with BioRender.com).