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. 2022 Jul 6;15:901466. doi: 10.3389/fnmol.2022.901466

Figure 4.

Figure 4

Expression of C-LTMR-specific markers in Meis1cko and control DRGs at different axial levels. (A–U) ISH and RNAscope were used to examine the expression of TH, Wfdc2 and Ceacam10 in cervical (C6/C7), thoracic (T7/T8) and lumbar (L4/L5) DRGs from 3 pairs of P60 Meis1cko and control mice. (A–G) TH expression was unchanged at different axial levels. (H–N) The number of Wfdc2+ neurons was significantly decreased in cervical and lumbar DRGs (in C6/C7: 24.5 ± 3.1 in control mice, 10.4 ± 0.8 in Meis1cko mice, p < 0.0001; in L4/L5: 27.9 ± 2.3 in control mice, 20.8 ± 1.6 in Meis1cko mice, p = 0.0131). (O–U) The number of Ceacam10+ neurons was obviously reduced in cervical DRGs (16.0 ± 2.2 in control mice, 6.6 ± 0.5 in Meis1cko mice, p < 0.0001). Error bars represent the SEM. Significant differences were determined using unpaired Student's t-test: *p < 0.05 and ***p < 0.001. ns, Not significant. Scale bar: 50 μm.