Table 2. Variables Associated With Failure to Downstage in 413 Patients Beyond Milan Criteria Undergoing Locoregional Therapy.
| Variable | Univariable | Multivariable | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| >3 vs ≤3 Tumors at diagnosis | 2.26 (1.20-4.27) | <.01 | 2.34 (1.22-4.50) | .01 |
| Largest initial tumor size, >7 vs ≤7 cm | 2.19 (1.03-4.66) | .043 | 2.62 (1.20-5.75) | .02 |
| No. of locoregional therapies | ||||
| 2 vs 1 | 1.11 (0.58-2.13) | .76 | ||
| ≥3 vs 1 | 0.75 (0.38-1.49) | .41 | ||
| α-Fetoprotein level response to locoregional therapy | ||||
| <20 ng/mL At transplant | 1 [Reference] | NA | 1 [Reference] | NA |
| ≥20 ng/mL And improved ≥50% from maximum at transplant | 0.89 (0.26-3.03) | .85 | 0.75 (0.22-2.59) | .65 |
| ≥20 ng/mL And <50% improved from maximum at transplant | 2.04 (1.18-3.52) | .001 | 1.99 (1.14-3.46) | .01 |
Abbreviations: NA, not applicable; OR, odds ratio.