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. 2022 Jun 28;13:884290. doi: 10.3389/fimmu.2022.884290

Figure 2.

Figure 2

Gal-9+ NK cells are impaired relative to Gal-9- NK cells in CHB patients. (A) Comparison of the expression of IFN-γ, TNF-α, CD107a, granzyme B, and perforin in circulating NK cells from CHB patients and HCs. (B) Comparison of the expression of IFN-γ, TNF-α, CD107a, granzyme B, and perforin in circulating NK cells from Tolerant, Active, and Inactive CHB patients and HCs. (C) Representative flow cytometry plots showing the expression of IFN-γ, TNF-α, and granzyme B in circulating Gal-9+ NK cells and Gal-9- NK cells from CHB patients. (D) Comparison of the percentages of IFN-γ, TNF-α, and granzyme B secreted by Gal-9+ NK cells and Gal-9- NK cells in peripheral blood from CHB patients. Results are expressed as the mean ± SEM, and the number of samples (n) in each group was ≥ 3. One-way ANOVA test was conducted for four-group comparisons. Groups with significant differences are marked, and the unmarked paired groups have no differences. An unpaired t-test was used to compare two independent groups. A paired t-test was used to compare paired samples. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.