Skip to main content
. 2022 Jun 28;13:884290. doi: 10.3389/fimmu.2022.884290

Figure 5.

Figure 5

Exogenous Gal-9 induces circulating CD8+ T cell exhaustion in active CHB patients. (A–G) Coculture of CD8+ T cells from active CHB patients and rhGal-9 for 3 days and stimulation with anti-CD3/anti-CD28. (A) The percentage of TIM-3+CD8+ T cells after culture with or without rhGal-9. (B) The percentage of CD69+CD8+ T cells after culture with or without rhGal-9. (C) Comparison of CD8+ T cell early apoptosis after culture with and without rhGal-9. (D–G) Comparison of the expression of IFN-γ, TNF-α, CD107a, and granzyme B in CD8+ T cells from active CHB patients after culture with and without rhGal-9. Results are expressed as the mean ± SEM, and the number of samples (n) in each group was ≥ 3. A paired t-test was used to compare paired samples. *P < 0.05; **P < 0.01; ***P < 0.001.