Table 3.

Risk of bias of included nRCTs

Study	Domains
	Bias due to confounding	Bias in selection of participants	Bias in classification of interventions	Bias due to deviations from intended interventions	Bias due to missing data	Bias in measurement of outcomes	Bias in selection of the reported result
Desplenter et al., 2013 [27]	Moderate	Low	Low	Low	NI	Moderate	Moderate
Gervasoni et al., 2010 [28]	Serious	Low	Moderate	Low	NI	Low	Low
Myers and Calvert, 1976 [47]	NI	NI	Low	Low	Moderate	Moderate	Moderate
Klang et al., 2015 [39]	Moderate	NI	Low	Low	Moderate	Moderate	Moderate
Meglic et al., 2010 [45]	Moderate	Low	Moderate	Low	Moderate	Moderate	Moderate

Serious Serious risk of bias, Moderate Moderate risk of bias, Low Low risk of bias

NI No information, nRCTs non-randomized controlled trials