Table 1.

Substrates of ADAM17

Cytokines	Receptors	Adhesion molecules
CD44 [117] CX3CL1 [252, 253] FLT-3L [254] Jagged 1 [38] Kit-ligand 1 and 2 [255] LAG-3 [256] MICA [257] MICB [258] RANKL [259] TNF-α [20, 260, 190, 261, 4, 11] TNF beta [262]	ACE2 [263-265] APOER [266] CD30 [267] CD40 [268] CD89 [269] EMMPRIN [135] EPCR [83] Ephrin B4 [135] ErbB4 [270, 271] GHR [272, 273] GPIba [274] GPV [275] GPVI [276] IL-1R II [21] IL6R [277, 278] Integrin beta-1 [150] Leptin receptor [279] LOX-1 [280] M6P/IGF2R [281] Notch1 [282, 283] NPR [284] p55 TNF alpha RI [20, 21] P75 TNF receptor [113] p75NTR [285, 21] Ptprz [286] syndecan 1 and 4 [287] Toll-like receptor 4 [288] TrkA [289] VEGFR [31] VPS10p [290]	ALCAM [291] CD44 [198, 117] CD62L [292] collagen XVII [293] desmoglein-2 [291] EpCAM [294] ICAM-1 [111] JAM-A [123] L-selectin [113] L1-CAM [295] PTP-LAR [296] NCAM [297] nectin-4 [298] PECAM-1 [135] VCAM-1 [109, 299]
Growth factors		Others
Amphiregulin [300, 190, 301] CSF-1 [138] Epigen [302] Epiregulin [190] HB-EGF [135, 300, 190, 303] IGFR1 [135] Neuregulin-1 [199] Pref-1 [282, 304] SEMA4D [305, 306] TGF alpha [113, 300] Tomoegulin-2 [307]		APP [308, 309] CD163 [310] KIM-1 [311] Klotho [312] MerTK [313] PMEL17 [314] PrPc [315] Tim-3 [316] VASN [317]