Table 2.

Cardiovascular-related substrates of ADAMs

	Inflammation	Angiogenesis	Proliferation/migration	Others
ADAM8	CD16 [318] CD23 [319] CX3CL1 [318] L-selectin [320] TNF alpha [318] TNFR1 [321] VCAM-1 [322]		TGF alpha [318]
ADAM9	CD40 [210] VCAM-1 [210]	Notch [282] Tie-2 [210] VE-cadherin [210] VEGFRII [210]	HB-EGF [323]	ADAM10 [324, 325] EphB4 [210]
ADAM10	CD44 [117] CX3CL1 [181] CXCL16 [182] IL6R [183] RAGE [184] TNF alpha [185]	E-cadherin [326] JAM-A [123] N-cadoherin [221] Notch1 [186, 282] Notch2 [327] NRP-1 [31] VEGFRII [188] VE-cadherin [189]	Betacellulin [190, 191] HB-EGF [63]	CD84 [328] Corin [195] DDR1 [193] Klotho [109] Meprin A [196] Neuregulin [329] RANKL [194]
ADAM12		E-cadherin [330] IFGBP3 [331] IFGBP5 [331] Notch1 [282]	Betacellulin [332] HB-EGF [333]
ADAM15		E-caderin [334] VEGFR [335]	FGFR2iiib [331]	ADAM10 [325]
ADAM17	CD40 [268] CD44 [117] CD163 [310] CX3CL1 [252, 253] ICAM-1 [111] IL-1R II [21] IL6R [277, 278] L-selectin [113] L1-CAM [295] p55 TNF alpha RI [20, 21] P75 TNF receptor [21, 113] PECAM-1 [135] TNF alpha [4, 11, 20, 190, 260, 261] VCAM-1 [109, 299]	JAM-A [123] Notch1 [282, 283] VEGFR [31]	HB-EGF [135, 190, 300, 303] IGFR1 [135] Pref-1 [282, 304] SEMA4D [305] syndecan 1 and 4 [287] TGF alpha [113, 300]	ACE2 [263–265] EPCR [83] Ephrin B4 [135] Jagged 1 [38] Klotho [312] RANKL [259]
ADAM19	Alpha 2 macroglobulin [336] TNF alpha [20, 337]	Neuregulin [231, 338]		(pro)renin receptor [339] RANKL [337]
ADAM28	TNF alpha [234]	IGFBP3 [340]	CTGF [341]	vWF [342]
ADAM33				RANKL [343]