Skip to main content
. 2022 Jul 21;16:100156. doi: 10.1016/j.medntd.2022.100156

Fig. 5.

Fig. 5

Effect of CEP on the N-Glycosylation of GX_P2V viral Proteins. A. Expression levels of N-glycosylation of viral proteins at indicated sites in presence or absence of CEP. B, C and D, indicate the side, top and bottom views of viral Spike protein (in closed state, PDB: 6VXX), respectively. All the N-glycosylation sites on the three chains of S protein affected by CEP are labelled. The N-glycosylation sites close to virus body are labelled in green, and those sites located at far-end of virus body are labelled in red. E and F. Side views of viral Spike protein (the N-glycosylation sites affected by CEP are labelled on B chain (Fig. 5E, PDB: 6VXX, closed state; Fig. 5F, PDB: 6VYB, open state)). Blue, NAG, N-linked glycan to the B chain of viral Spike protein; Magentas, the N-glycosylation sites located on the RBD of viral S protein; Green, the N-glycosylation sites affected by CEP on B chain of S protein close to virus body. Red, the CEP-affected N-glycosylation sites located on N-terminus of B chain. G. Cartoon display of CEP-affected N-glycosylation sites on Spike protein on the coronavirus surface. Note: Since the 3D structure of GX_P2V viral S proteins is not available, considering the high sequence similarity between SARS-CoV-2 and GX_P2V, we adopted the 3D structure of SARS-CoV-2 (6VXX, closed state; 6VYB, closed state) to draw the pictures. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)