Figure 2.

Global fitting of IAPP aggregation kinetics in the presence of LUVs. (A) Fits of ThT aggregation data to a nucleation elongation model with a reaction order for nucleation (n_c) of 2. (B) Fits to a model in which secondary nucleation dominates and both reaction orders for primary (n_c) and secondary nucleation (n₂) are equal to 1. (C) Fits to a model in which secondary nucleation dominates and both reaction orders are equal to 2. (D) Fits to a fragmentation-dominated model. The aggregation assay was performed in the presence of 7:3 DOPC:DOPS vesicles at a total IAPP:lipid molar ratio of 1:100.