Table 3.
Multivariable analysis of risk factors for delayed post-ICH dementia conversion in patients with probable CAA
| Variables | HR | 95% CI | p |
|---|---|---|---|
| Model 1 (demographic factors) | |||
| Age (per year) | 1.042 | 0.989–1.098 | 0.123 |
| Education (score) | 0.66 | 0.361–1.208 | 0.178 |
| MCI (yes versus no) | 4.617 | 1.848–11.536 | 0.001* |
| Model 2 (neuroimaging factors) | |||
| Disseminated cSS (yes versus no) | 3.115 | 1.030–9.424 | 0.044* |
| WMH (Fazekas score) | 1.439 | 1.036–2.001 | 0.03* |
| Lobar CMBs≥5 | 1.105 | 0.431–2.834 | 0.835 |
| WMH/TBV (%)# | 1.480 | 1.157–1.891 | 0.002* |
| Model 3 (sensitivity analysis: factors combined) | |||
| MCI (yes versus no) | 5.880 | 2.250–15.367 | <0.001* |
| Disseminated cSS (yes versus no) | 3.275 | 1.129–9.499 | 0.029* |
| WMH (Fazekas score) | 1.427 | 1.057–1.927 | 0.02* |
| WMH/TBV (%)# | 1.426 | 1.112–1.830 | 0.005* |
| Model 4 (sensitivity analysis: factors combined) | |||
| MCI (yes versus no) | 6.043 | 2.401–15.212 | <0.001* |
| SVD score for CAA≥3 | 2.961 | 1.278–6.861 | 0.011* |
Model 1 and model 2 included demographic factors and neuroimaging factors separately, and factors survived from model 1 and model 2 were then included in model 3. Model 4 used SVD score for CAA to replace individual neuroimaging markers.
#
WHM/TBV (%) was included in the model to replace WHM Fazekas score.
*
with statistical significance.
HR, hazard ratio; MCI, mild cognitive impairment; CMBs, cerebral microbleeds; WMH, white matter hyperintensity; cSS, cortical superficial siderosis; SVD, small vessel disease; CAA, cerebral amyloid angiopathy.