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. Author manuscript; available in PMC: 2022 Jul 21.
Published in final edited form as: Pediatrics. 2020 Jan;145(1):e20191930. doi: 10.1542/peds.2019-1930

TABLE 2.

Combination Test Results by Age Group and Nativity

Test Result Combination All Ages <2 y 2–4 y 5–9 y 10–14 y

Born in the United States
 Two test combinations
  TST+ and IGRA+a, n (%) 43 (15.0)b 0 (0.0) 9 (18.4) 18 (16.8) 16 (14.6)
  TST+ and IGRA−c, n (%) 14 (4.9)b 0 (0.0) 2 (4.1) 6 (5.6) 6 (5.5)
  TST− and IGRA+, n (%) 9 (3.1) 1 (4.8) 0 (0.0) 2 (1.9) 6 (5.5)
  TST−and IGRA−, n (%) 221 (77.0) 20 (95.2) 38 (77.6) 81 (75.7) 82 (74.6)
 Three test combinations
  Triple +d, n (%) 31 (10.9) 0 (0.0) 6 (12.2) 14 (13.2) 11 (10.1)
  Triple −e, n (%) 218 (76.8) 19 (95.2) 38 (77.6) 80 (75.5) 81 (74.3)
Born outside of the United States
 Two test combinations
  TST+ and IGRA+, n (%) 263 (8.0)b 1 (0.5) 22 (3.5) 79 (6.8) 161 (12.3)
  TST+ and IGRA−, n (%) 638 (19.3)b 64 (32.5) 132 (20.9) 168 (14.4) 274 (20.9)
  TST−and IGRA+, n (%) 54 (1.6) 1 (0.5) 5 (0.8) 22 (1.9) 26 (2.0)
  TST− and IGRA−, n (%) 2349 (71.1) 131 (66.5) 472 (74.8) 897 (76.9) 849 (64.8)
 Three test combinations
  Triple +, n (%) 195 (6.1) 1 (0.5) 11 (1.8) 61 (5.4) 122 (9.7)
  Triple −, n (%) 2272 (70.9) 126 (66.3) 458 (74.2) 872 (76.6) 816 (64.7)

−, negative; +, positive.

a

QFT-GIT–positive or T-SPOT–positive result.

b

P < .001 for comparison of born in the Unites States to not born in the United States.

c

QFT-GIT–negative and T-SPOT–negative results.

d

TST-positive, QFT-GIT–positive, and T-SPOT–positive results.

e

TST-negative, QFT-GIT–negative, and T-SPOT–negative results.