Table 2.
Linear regression between diffuse fibrosis by T1-mapping cardiac magnetic resonance and clinical, electrical, and imaging parameters
| Univariate B (95% CI) Lateral T1 (ms) | P value | Univariate B (95% CI) Lateral ECV (%) | P value | |
|---|---|---|---|---|
| Clinical characteristics | ||||
| Agea (years) | 4.95 (−3.43–13.33) | 0.24 | 0.52 (−0.12–1.16) | 0.11 |
| Sex, female | 0.95 (−24.20–26.10) | 0.69 | 1.66 (−0.15–3.47) | 0.07 |
| Syncope | 39.96 (−0.88–80.79) | 0.06 | 1.36 (−1.69–4.41) | 0.38 |
| Palpitations | 14.58 (−11.81–40.96) | 0.27 | 0.96 (−1.01–2.94) | 0.33 |
| Arrhythmias | ||||
| VA | 36.68 (11.37–61.99) | 0.005 | 2.07 (0.16–3.98) | 0.03 |
| Severe VA | −25.87 (−116.61–64.87) | 0.57 | −1.29 (−7.88–5.31) | 0.70 |
| Electrocardiogram | ||||
| TWI | 27.94 (1.81–54.07) | 0.04 | 2.31 (0.42–4.19) | 0.02 |
| QRS duration (ms) | 0.49 (−0.46–1.44) | 0.30 | 0.01 (−0.07–0.08) | 0.89 |
| QRS fragmentation | −16.48 (−54.22–21.27) | 0.39 | −1.54 (−4.40–1.31) | 0.28 |
| QTc (ms) | 0.44 (0.05–0.83) | 0.03 | 0.06 (0.03–0.08) | <0.001 |
| 24 h Holter monitoring | ||||
| PVCs count,bn | 18.21 (5.51–30.94) | 0.006 | 1.17 (0.16–2.18) | 0.03 |
| Cardiac magnetic resonance | ||||
| Bileaflet MVP | 21.17 (−3.98–46.33) | 0.10 | 1.75 (−0.08–3.58) | 0.06 |
| Inferolateral MAD distance | 4.50 (1.26–7.73) | 0.007 | 0.27 (0.02–0.52) | 0.03 |
| LVEDVic (mL/m2) | 1.93 (−0.86–4.72) | 0.17 | 0.13 (−0.08–0.33) | 0.21 |
| LVEDVic (mL/m2) | 4.49 (−1.20–10.19) | 0.12 | 0.32 (−0.09–0.74) | 0.13 |
| LV EFc (%) | −4.01 (−15.42–7.39) | 0.68 | −0.45 (−1.28–0.37) | 0.28 |
| LGE | 12.10 (−13.16–37.36) | 0.34 | 1.10 (−0.75–2.95) | 0.24 |
| Basal LV wall LGE | 23.64 (−4.80–52.08) | 0.10 | 2.24 (0.18–4.29) | 0.03 |
| Papillary muscles LGE | 20.39 (−21.03–61.81) | 0.33 | 3.30 (0.37–6.23) | 0.03 |
P values are calculated by univariate linear regression analysis. Bold values denote statistical significance.
ECV, extracellular volume; EF, ejection fraction; LGE, late gadolinium enhancement; LV, left ventricular; LVEDVi, LV end-diastolic volume indexed; LVESVi, LV end-systolic volume indexed; MAD, mitral annulus disjunction; MVP, mitral valve prolapse; PM, papillary muscles; PVCs, premature ventricular contractions; TWI, T-wave inversion; VA, ventricular arrhythmias.
Per 10 years increments.
Log base 10 transformation of the PVCs count was performed to assure model linearity assumptions.
Per 5-units increments.