Table 3.

Comparison of Age-Matched Sibling Pairs' Atrophy Area and Effective Radius Growth Rates

Family No.	Genotype Class*	Patient No.	Sex	Age-Match (years)	Duration of Follow-Up (years)	Visual Acuity Change				Age-Matched Progression Rates in DAF				Inter-sibling Differences in DAF Growth
						Baseline		Final		Area Growth Rate (mm2/year)		Radius Growth Rate (mm/year)		Area Growth Rate (mm2/year)		Radius Growth Rate (mm/year)
						Right	Left	Right	Left	Right	Left	Right	Left	Right	Left	Right	Left
F1	B	P1	M	29	7.04	6	17	5	19	3.27	3.12	0.21	0.19	1.117	1.233	0.009	0.0004
		P2	M	29	8.51	23	30	20	31	2.15	1.89	0.22	0.19
F2	B	P3	F	30	3.67	35	35	34	35	1.01	0.30	0.20	0.07	0.870	0.147	0.165	0.042
		P4	M	30	7.21	62	40	38	36	0.14	0.15	0.03	0.03
F3	A	P5	F	39	2.67	15	38	12	31	0.45	1.73	0.02	0.06	0.273	0.442	0.013	0.031
		P6	M	38	8.72	15	20	15	20	0.72	2.17	0.03	0.09
F4	B	P7	M	58	5.14	9	9	10	7	3.89	3.19	0.12	0.10	0.917	1.075	0.062	0.074
		P8	M	58	1.48	3	2	1	1	4.81	4.27	0.18	0.17
F5	B	P9	F	57	3.66	86	86	80	82	2.02	1.34	0.15	0.23	0.467	0.006	0.043	0.008
		P10	M	57	4.51	56	81	−15	33	1.55	1.33	0.19	0.24
F7	A	P13	M	18	2.53	42	63	31	35	0.36	0.04	0.05	0.01	0.176	0.205	0.032	0.018
		P14	F	18	7.76	35	35	29	33	0.18	0.24	0.02	0.02
F10	B	P19	M	75	3.55	−30	−30	−30	−30	1.15	1.52	0.06	0.07	1.539	0.813	0.037	0.023
		P20	F	75	5.27	−30	−30	−30	−30	2.69	2.33	0.09	0.09
F14	A	P28	F	27	0.51	5	10	10	11	1.17	3.12	0.13	0.32	0.677	1.011	0.078	0.111
		P29	M	26	1.52	7	7	4	5	1.85	2.11	0.20	0.21

^*Definition: Class A, severe biallelic mutations. Class B, an allele of intermediate severity in trans with a severe or intermediate allele.

DAF, dark autofluorescence.