TABLE 2.
Differentially expressed genes in MeDALL and replication in EVA-PR
| Gene identifier | Known in allergy |
Known in immune process |
MeDALL |
EVA-PR |
||||
|---|---|---|---|---|---|---|---|---|
| Any multimorbidity (62.1%) |
Any multimorbidity (51.1%) |
|||||||
| log2FC | P-value | FDR | log2FC | P-value | FDR | |||
| A. Multimorbidity | ||||||||
| CLC | Yes | Yes | 0.44 | 1.3E–08 | 8.8E–04 | 0.14 | 1.4E–04 | 4.4E–04 |
| SLC29A1 | No | No | 0.09 | 3.1E–07 | 7.1E–03 | 0.17 | 2.6E–06 | 1.9E–05 |
| HRH4 | Yes | Yes | 0.20 | 4.7E–07 | 7.1E–03 | 0.12 | 1.1E–03 | 2.7E–03 |
| FRRS1 | No | No | 0.13 | 5.1E–07 | 7.1E–03 | 0.14 | 7.2E–05 | 2.6E–04 |
| LOC101929979a | N/A | N/A | 0.32 | 5.7E–07 | 7.1E–03 | Nullb | Nullb | Nullb |
| IL5RA | Yes | Yes | 0.28 | 6.3E–07 | 7.1E–03 | 0.15 | 4.2E–05 | 1.8E–04 |
| CACNA1D | No | No | 0.04 | 3.3E–06 | 2.5E–02 | 0.07 | 3.9E–02 | >5E–02 |
| IL1RL1 | Yes | Yes | 0.20 | 3.3E–06 | 2.5E–02 | 0.09 | 1.2E–02 | 2.2E–02 |
| TTC7B | No | No | 0.08 | 4.6E–06 | 2.8E–02 | 0.03 | 3.3E–01 | >5E–02 |
| CYSLTR2 | Yes | Yes | 0.16 | 4.6E–06 | 2.8E–02 | 0.07 | 3.1E–02 | >5E–02 |
| EMR4P | No | Yes | 0.23 | 5.7E–06 | 3.0E–02 | 0.13 | 5.0E–04 | 1.4E–03 |
| PIK3R6 | No | Yes | 0.10 | 7.4E–06 | 3.6E–02 | 0.09 | 5.4E–03 | 1.1E–02 |
| ZSCAN29 | No | No | 0.06 | 9.6E–06 | 4.0E–02 | 0.03 | >5E–02 | >5E–02 |
| Gene Identifier | Known in allergy |
Known in immune process |
MeDALL |
EVA-PR |
||||
| Rhinitis alone (53.4%) |
Rhinitis alone (42.1%) |
|||||||
| log2FC | P-value | FDR | log2FC | P-value | FDR | |||
| B. Rhinitis alone | ||||||||
| SENP1 | No | No | 0.06 | 7.4E–07 | 1.4E–03 | 0.00 | >5E–02 | >5E–02 |
| BCAP29 | No | Yes | 0.07 | 3.3E–06 | 5.0E–03 | −0.01 | >5E–02 | >5E–02 |
| CEBPE | No | Yes | 0.11 | 3.6E–06 | 5.3E–03 | 0.11 | 1.6E–02 | >5E–02 |
| FAM66C | No | Yes | −0.03 | 6.5E–06 | 8.6E–03 | 0.07 | >5E–02 | >5E–02 |
| TNFSF14 | Yes | No | 0.15 | 7.9E–06 | 1.0E-02 | −0.08 | >5E–02 | >5E–02 |
| RNA5SP378a | N/A | N/A | −0.08 | 1.3E–05 | 1.6E–02 | Nullb | Nullb | Nullb |
| MAGEA9B | No | No | −0.05 | 1.5E–05 | 1.7E–02 | Nullb | Nullb | Nullb |
| RP1-149A16.12a | N/A | N/A | −0.07 | 1.6E–05 | 1.8E–02 | Nullb | Nullb | Nullb |
| RNA5SP335a | N/A | N/A | 0.10 | 1.7E–05 | 1.8E–02 | Nullb | Nullb | Nullb |
| LOC101928812a | N/A | N/A | 0.09 | 2.0E–05 | 1.9E–02 | −0.05 | >5E–02 | >5E–02 |
| LEPREL4 | No | No | −0.03 | 2.5E–05 | 2.2E–02 | 0.01 | >5E–02 | >5E–02 |
| CLINT1 | No | No | 0.05 | 2.7E–05 | 2.3E–02 | 0.00 | >5E–02 | >5E–02 |
| NDUFB5 | No | No | 0.05 | 2.7E–05 | 2.3E–02 | 0.00 | >5E–02 | >5E–02 |
| NPIPB5 | No | No | −0.08 | 3.2E–05 | 2.6E–02 | 0.05 | >5E–02 | >5E–02 |
| LA16c-395F10.1a | N/A | N/A | 0.09 | 3.4E–05 | 2.7E–02 | Nullb | Nullb | Nullb |
| AK2 | No | Yes | 0.04 | 3.9E–05 | 3.1E–02 | 0.01 | >5E–02 | >5E–02 |
| GLT6D1 | No | No | −0.08 | 3.9E–05 | 3.1E–02 | Nullb | Nullb | Nullb |
| MIR539 | No | No | −0.11 | 4.2E–05 | 3.2E–02 | Nullb | Nullb | Nullb |
| LOC101927780a | N/A | N/A | 0.08 | 4.2E–05 | 3.2E–02 | 0.18 | 1.3E–04 | 2.3E–03 |
| RNA5SP440a | N/A | N/A | −0.09 | 4.4E–05 | 3.3E–02 | Nullb | Nullb | Nullb |
| DUSP16 | No | No | 0.10 | 5.0E–05 | 3.5E–02 | −0.01 | >5E–02 | >5E–02 |
| GPR65 | No | Yes | 0.09 | 5.1E–05 | 3.5E–02 | 0.03 | >5E–02 | >5E–02 |
| RNF149 | No | No | −0.05 | 5.2E–05 | 3.5E–02 | −0.03 | >5E–02 | >5E–02 |
| SLC25A40 | No | No | 0.06 | 5.2E–05 | 3.5E–02 | −0.02 | >5E–02 | >5E–02 |
| EXOC5 | No | No | 0.04 | 5.8E–05 | 3.8E-02 | 0.01 | >5E–02 | >5E–02 |
| HMGA1P4 | No | No | 0.10 | 7.3E–05 | 4.4E–02 | Nullb | Nullb | Nullb |
| LOC101929526a | N/A | N/A | 0.09 | 8.2E–05 | 4.8E–02 | Nullb | Nullb | Nullb |
Note: Differentially expressed genes with log2FC and FDR p-values in A. any multimorbidity sorted by increasing FDR, or B. rhinitis alone for MeDALL and EVA-PR participants. Power of each group in parenthesis (%). P-values < .05 are in bold.
a
Long intergenic nonprotein coding RNA, pseudogenes or ribosomal pseudogenes, their role in allergy or immune processes could not be determined (N/A: not applicable)
b
null: not tested due to QC and RNA Sequencing issues. Genes that were specific for asthma, dermatitis, and rhinitis multimorbidity are not shown (ACSM3, SIGLEC8, ALOX15, ALOX15P1, BACE2-IT1, LGALS12, PNPLA6, SEMA7A, SMPD3, and SORD).