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. Author manuscript; available in PMC: 2022 Jul 21.
Published in final edited form as: Nature. 2021 Sep 1;597(7875):285–289. doi: 10.1038/s41586-021-03856-x

Fig. 1. Structural features unique to PIWIs.

Fig. 1.

a, Segmented EfPiwi-piRNA cryo-EM reconstruction, colored by domain. b, Cartoon representation of EfPiwi model. Disordered piRNA nucleotides, dashed red line. Linear domain schematic shown below. c, Density maps (grey mesh) in space occupied by seed regions of hAgo2 (PDB 4OLA) and EfPiwi. Modeled guide RNAs as red sticks. d, Superposition of miRNA-class AGO structures (left, PDB: 4KXT, 4OLA, 5VM9, 6OON) and known PIWI structures (right, PDB: 7KX7, 5GUH, 6KR6). AGO central-gate and PIWI seed-gate structures indicated.