FIG 7.

Persistence of Bpm in vivo after levofloxacin treatment. (A) Weight change during the 21 days of infection. Vertical dotted line represents the challenge day; horizontal dotted line shows the endpoint established in the protocol. (B) Survival graph of mice infected with wild type K96243 or mutant ΔhigB for 21 days postchallenge. (C) Bacterial burden in lungs, liver, and spleen of n = 9 mice challenged with each strain ± SD. (D) Images of gross pathology of infected spleens of mice infected with wild type of ΔhigB after treatment. Two-way ANOVA was used to establish statistical differences (C). *, P < 0.05.