Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 8;42(7):e00563-21. doi: 10.1128/mcb.00563-21

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 American Society for Microbiology.

All Rights Reserved.

PMC Copyright notice

FIG 2 — Mice without Keap1- and β-TrCP-mediated Nrf2 degradation pathways exhibit severe growth retardation. (A) Schematic showing the mutant mice with Keap1 knocked down and the Nrf2^SA mutation. We crossed the Nrf2^SA/SA mice with two types of Keap1 knockdown mice: Keap1^FA/FA and Keap1^FA/– mice. (B) Body weight changes in Keap1^+/+::Nrf2^+/+, Keap1^+/+::Nrf2^SA/SA, Keap1^FA/FA::Nrf2^+/+, Keap1^FA/FA::Nrf2^SA/SA, Keap1^FA/–::Nrf2^+/+, and Keap1^FA/–::Nrf2^SA/SA male (left) and female (right) mice. Keap1^FA/–::Nrf2^SA/SA mice exhibit severe growth retardation. The line graphs show the means ± SD. **, P < 0.01, and *, P < 0.05, compared with Keap1^FA/–::Nrf2^+/+ mice by one-way ANOVA with Dunnett’s multiple-comparison test. (C) Representative images of Keap1^+/+::Nrf2^+/+, Keap1^+/+::Nrf2^SA/SA, Keap1^FA/FA::Nrf2^+/+, Keap1^FA/FA::Nrf2^SA/SA, Keap1^FA/–::Nrf2^+/+, and Keap1^FA/–::Nrf2^SA/SA mice.